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If an opioid analgesic is initiated in a affected individual presently taking a benzodiazepine or CNS depressant: A lower Preliminary dose with the opioid analgesic is usually recommended; titrate according to clinical reaction.Oxycodon kan disfunctie en spasme van de sfincter van Oddi veroorzaken, waardoor de intrabiliaire druk toeneemt en het ris

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